Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

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4E-BP restrains eIF4E phosphorylation

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4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

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Eukaryotic initiation factor (eIF) 4E-binding proteins (4E-BPs) are translational repressors that bind specifically to eIF4E and are critical in the control of protein translation. 4E-BP2 is the predominant 4E-BP expressed in the brain, but their role is not well known. Here, we characterized four forms of 4E-BP2 detected by two-dimensional gel electrophoresis (2-DGE) in brain. The form with hi...

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Eukaryotic translation initiation factor 4E (eIF4E) is the mRNA 5' cap binding protein, which plays an important role in the control of translation. The activity of eIF4E is regulated by a family of repressor proteins, the 4E-binding proteins (4E-BPs), whose binding to eIF4E is determined by their phosphorylation state. When hyperphosphorylated, 4E-BPs do not bind to eIF4E. Phosphorylation of t...

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ژورنال

عنوان ژورنال: RNA

سال: 2008

ISSN: 1355-8382

DOI: 10.1261/rna.950608